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De Iuliis A, Montinaro E, Fatati G, Plebani M, Colosimo C

The three GLP-1 medications approved by the FDA to treat obesity include: Liraglutide (Saxenda/Victoza) Semaglutide (Wegovy/Ozempic/Rybelsus) Tirzepatide (Zepbound/Mounjaro) GLP-1 medications can lead to an average weight loss of 10% to 20% over 12-24 months when used alongside healthy diet and exercise changes

Occasional GI upset could interfere with sleep

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The gap between "metabolically active" and "therapeutically effective" matters when weight loss is your goal

Additionally, while mice remained unrestrained during the hyperinsulinemic-euglycemic clamps, they were sampled by the tail vein, which may contribute differential physiological responses to stress across genotypes