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We also observed frequent overlap between FOXO4 and p53bp1 foci, indicating an interaction and co-localization between FOXO4 and p53 in the nuclei of senescent cells (Figure

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[3] The doses used in these tendon studies typically ranged from 10 to 200 micrograms per kilogram of body weight, administered once daily, which when extrapolated to a 75-kilogram human would suggest a working range of approximately 200 to 500 micrograms per day

The metabolic activity during both time frames may be different due to learning, habituation and fatigue effects