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V.Correa MarreroM.et al (2020)

Tirzepatide is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus (Mounjaro) and chronic weight management (Zepbound)

The brown pigment is lipofuscin in macrophages, not melanin

R GSTP1 (pi class) has a common variant, Ile105Val (rs1695), that reduces catalytic efficiency for polycyclic aromatic hydrocarbons but increases activity toward certain drug substrates

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