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Functional validation of CYP3A4 activity through rifampicin induction and ketoconazole inhibition demonstrated metabolic competence comparable to existing in vitro liver models, including HepaRG cells and primary human hepatocytes

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There is research into phages that target Enterobacteriaceae or Proteobacteria overgrowth, which could be relevant for PD where those are elevated [277]

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monotherapy doses in the Phase 2 dose-finding trial spanned 0.3 mg to 4.5 mg, with 2.4 mg used in the CagriSema combination