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A meta-analysis of randomized controlled trials by Fujiya et al

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Compared to metformin, thiazolidinediones act more effectively on peripheral tissues (adipose tissue, muscle) than on the liver due to the specific distribution of their target receptors [55]

Prognosis Diabetic gastroparesis is associated with higher morbidity, including increased hospitalizations and emergency department and hospital visits

Therefore, FXR signaling can modulate the gut microbial composition and regulate hepatic metabolism