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Aldiss P, Davies G, Woods R, et al
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Most nutritionists suggest taking it in the morning, on an empty stomach, around 2030 minutes before breakfast
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Dihydrofolate reductase (DHFR) which catalyzes the conversion of dihydrofolate into tetrahydrofolate, the active form of folic acid, is competitively inhibited by MTX and MTX-PGs, which depletes vital tetrahydrofolate (THF) needed for cellular functions (Xu et al
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