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Consistent with these findings, immunoprecipitation of F-SNIP1 E366G, K265G, and double mutant K265G/K301G revealed moderate (for E366G) and severe (for K265G and K265G/K301G) reductions in association with components of the activated spliceosome (P-SF3B1, CWC22, RBM22 and BUD13) (Supplementary Fig

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