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By initiating the breakdown of L-tyrosine in the proximal region of the small intestine with consequent reduction of the quantity reaching the colon and by competing with the native gut microbiota in the colon implicated in p-cresol generation from L-tyrosine, the therapeutic strain exerts its activity in CKD patients

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Another possibility is that there is an association of this SNP with another disease that is highly correlated with depression

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doi: 10.1136/oem.31.3.245