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Next, we confirmed that the observed reduction in neuronal death was associated with an increase in apoptosis induction through cleaved caspase-3 staining, which detects apoptotic cells

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This increase could have resulted in the increase in food and water intakes of rats

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It selectively activates GHS-R1a without meaningfully stimulating ACTH or prolactin release, even at doses that produce comparable GH pulses to GHRP-2