The drug enhances insulin secretion in a glucose-dependent manner, meaning it stimulates insulin release only when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia
Weight loss typically averages 810% of initial body weight over 56 weeks
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While the 2.5 mg dose is intended as a starter dose, some individuals are super-responders who see consistent results at this level
In addition, semaglutide slows down the emptying of the stomach, which keeps someone feeling fuller longer after eating and to help curb over eating
Likewise, GLP-1RAs can lower postprandial glycemia predominantly by slowing gastric emptying and promoting weight loss [6, 7]