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Numerous data indicate the importance of GSH and the GSH/GSSG ratio in the regulation of tumor cell viability, in the initiation of tumor development, progression, and drug resistance

Preliminary X-ray crystallographic analysis of glutathione transferase Zeta 1 (GSTZ1a-1a)

In addition to GLS inhibitors, strategies that target the conversion of glutamate to -ketoglutarate, such as GDH inhibitors and transaminase inhibitors, have also been evaluated in preclinical models of breast cancer and neuroblastoma..

Figure 1 Ferroptosis, first characterized by the Brent R

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