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Hormonal pathways: evidence suggests NNMT influences pathways controlling adipocyte differentiation

These may include: Nausea, vomiting or diarrhoea (most common early on) Constipation Fatigue Mild increases in heart rate (similar to changes seen with GLP-1 medicines) Side effects were more frequent at higher doses (8 mg and 12 mg), but still rated mild to moderate overall

TikTok calls it the vacation peptide. The compound is melanotan II, and its more famous nickname, the Barbie drug, has been showing up in dermatology journals since at least 2010 for the tan, plus a side effect serious enough that it later spun off its own FDA-approved libido drug

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Suzuki K, Akiyama M, Ishigaki K, Kanai M, Hosoe J, Shojima N, Hozawa A, Kadota A, Kuriki K, Naito M, Tanno K, Ishigaki Y, Hirata M, Matsuda K, Iwata N, Ikeda M, Sawada N, Yamaji T, Iwasaki M, Ikegawa S, Maeda S, Murakami Y, Wakai K, Tsugane S, Sasaki M, Yamamoto M, Okada Y, Kubo M, Kamatani Y, Horikoshi M, Yamauchi T, Kadowaki T

Previously, this factor was thought to be insignificant in typical conditions (Ruta et al., 2020)