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There is a warning about the possible increased risk of thyroid C-cell tumors in rodents, so tirzepatide should not be used by people with a personal or family history of medullary thyroid carcinoma or MEN2

Wegovy uses a higher dose for weight loss purposes

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10.1016/0167-4838(91)90095-H

This indicates that the transporter system significantly contributes to mediating BBB integrity and permeability of carrier mediated transport (Table 2)

[1][3] Symptoms are dose-dependent : they increase as the dose steps up and are most common in the first few weeks at each new level