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Elevated TFAM expression has been observed in drug-resistant hepatocellular carcinoma cells, and its inhibition has been shown to restore the chemosensitivity of these resistant cells, suggesting a potential therapeutic target for overcoming chemoresistance (229, 230)

Anti-anxiety effects in rats at 0.5 g/kg (extremely low dose) produced effects within 12 minutes of intraperitoneal injection, including increased time exploring open/lighted maze areas, decreased immobile freeze reaction time, and increased exploration in open field tests