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On the other hand, prostaglandin F2 (PGF2) was shown to exert anti-adipogenic effects in primary preadipocytes [163, 164, 165], 1246 cells [164], and 3T3-L1 cells [166, 167, 168]

Biopsy of the pancreas, liver or intestines may be performed

Administered intramuscularly or intravenously under medical supervision

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Future research should focus on large-scale, well-controlled randomized trials with standardized dosing protocols, clearly defined deficiency thresholds, and long-term follow-up to strengthen the evidence base and guide clinical practice

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