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Shanley et al

However, gastrointestinal side effects such as constipation may indirectly contribute to conditions like haemorrhoids or anal fissures that cause rectal bleeding

Therefore, peptide analogs of GLP-1 have been developed to treat type 2 diabetes and obesity, with the beneficial outcome of lowering cardiovascular risks 10,11

Preclinical studies have demonstrated that Retatrutides multi-receptor activation creates additive effects that exceed the sum of individual receptor stimulation