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Acknowledgements We acknowledge co-funding from the Fondazione per la Ricerca Biomedica Saverio e Isabella Cianciola and from Next Generation EU, in the context of the National Recovery and Resilience Plan, Investment PE8 Project Age-It: Ageing Well in an Ageing Society

It is therefore unsurprising that the LD 50 values for compounds 1 and 2 determined ex vivo have a similar discordance to that seen for PZQ when considering in vivo PK/PD: much like PZQ these compounds are schistosomicidal in vivo at sub LD 50 concentrations

The patients who stand to benefit most from dramatic weight loss interventions are often those with the fewest resources to navigate a $1,200-per-month drug bill

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These key themes from quantitative and qualitative studies were then mapped to construct a revised needs hierarchy that emphasizes autonomy, functionality, and adaptation

Bobeck, E