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For patients who have plateaued or not achieved their goal weight on Wegovy, switching under clinical supervision can be worthwhile

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Within the immune system, they inhibit NF-B and NLRP3 inflammasome activation, promote antiinflammatory IL-10 release, and promote macrophages and microglia toward antiinflammatory phenotypes (109, 110) (Figure 3), which could indirectly reduce cross-seeding of A and -synuclein initiated in the gut

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Contemporary guidelines increasingly reflect this paradigm