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This tripartite interplaydysbiosis-barrier dysfunction-immune activationconstitutes a self-perpetuating positive feedback loop, keeping periodontal tissues and the systemic circulation in a state of chronic inflammation for a long time, thereby inducing systemic diseases such as RA and CVD (158, 171, 175, 176)

and amino acids, peptides, and analogs for 17.14% (Fig

The inflammation can occur suddenly and without warning, and often with no related symptoms