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These findings suggest that the mitophagy induced by KU-57788 may be a stress response to mitochondrial damage, rather than a direct mechanism contributing to its anti-ATC activity

On LSD comparison, the difference was significant between each two individual groups as sperm counts and abnormal sperm forms percentage were significantly high in the PTU-treated and significantly decreased in the PTU&LC-treated group compared with the PTU-treated group

Rolipram, a phosphodiesterase-4 inhibitor, indirectly enhances proteasome activity by increasing cAMP levels and reduces tau aggregation in AD models

A decision is expected in Q4 2026 approximately October to December