M.MarchettiP.SalvatoriR.CorselloS
By coordinately modulating glucose, glutamine, lipid, and oxidative phosphorylation pathways, lactylation furnishes cancer cells with a rapid and adaptable metabolic programme that supports macromolecular synthesis, maintains an acidic and immunosuppressive microenvironment, and ultimately accelerates tumor progression and therapeutic resistance
Ratziu, V
Discovery and development of MEDI7247, a novel pyrrolobenzodiazepine (PBD)-based antibody drug conjugate targeting ASCT2, for treating hematological cancers
Sustaining the engine: mitochondrial quality control and transport networks As the central engine of cellular bioenergetics and intermediary metabolism, mitochondrial functional integrity is critical for sustaining high metabolic flux, anabolic potential, and therapeutic responsiveness in CRC [18]
Finasteride and dutasteride work because their steroid-like structure allows them to physically bind and inhibit the 5-alpha reductase enzyme