For some patients, prednisone's appetite effect completely overrides semaglutide's suppressant action, making weight loss nearly impossible during high-dose corticosteroid therapy
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doi: 10.1084/jem.20071094
Many studies have investigated the potential correlation between genetic background and hypogonadal dysfunction in individuals with PWS, but no data have shown an impact of the various genetic defects (such as 15q11-13 paternal deletion, mUPD, or imprinting defect) on pubertal development and fertility (203, 204)