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The same study revealed an association between disease-associated GCLC GAG trinucleotide repeat genotypes and decreased GCLC protein expression (Gysin et al

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in healthy aging, glucose metabolism is primarily reduced in the frontal cortex, whereas in AD, metabolic deficits are more pronounced in the parietal lobe and precuneus 73

We next conducted the same experiments using THP-1 cells, a human monocyte-derived macrophage model, and showed that KL1 similarly enhanced antibiotic killing in human macrophages (Fig