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PMID: 31237318

Moreover, MAGEL2 expression is disrupted in mice carrying mutations in the core circadian regulator CLOCK ( MAGEL2 is the only gene among those disrupted in Prader-Willi syndrome with expression and function linked to excessive daytime sleepiness and night waking, and while it is also mutated in Schaaf-Yang syndrome, circadian features in this disorder remain poorly characterized due to the small number of diagnosed individuals (Fountain et al., 2017

Importantly, these fat-reducing effects occurred without changes in lean tissue mass, suggesting selective targeting of adipose tissue