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In an experimental model using a lethal dose of 600 mg/kg APAP in adult wild-type mice, administering a high dose of 300 mg/kg NAC at 1-h post-APAP exposure resulted in significant therapeutic effectiveness, with 100% survival

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By employing small interfering RNA (siRNA) to knock down CSF-1R expression, studies have demonstrated successful reprogramming of TAMs, shifting them from the M2 phenotype to the M1 phenotype (Li et al., 2020)