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By synthesizing current evidence, we aim to provide a comprehensive understanding of the role of IF in cardiovascular health and stimulate discussions about optimized personalized dietary strategies for obesity management in the era of obesity pharmacotherapy

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"Perhaps doses that achieve modest weight loss but robust anti-inflammatory and vascular benefits might be appropriate for some indications, while maximum-tolerated doses remain appropriate for obesity," says Nadolsky

Therefore, the use of new technological advances such as single cell RNA-seq can shed new light on the GLP-1RA-dependent and independent effects and targets in animal models and humans [177]