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Coronary heart disease Coronary heart disease (CHD), a typical example of cardiometabolic diseases, represents the ultimate manifestation of accumulated metabolic dysregulation 135

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More recently, however, an animal study based on a tandem stenosis mouse model showed the ability of SGLT2is to stabilize atherosclerotic plaques, with increased fibrosis, augmented collagen accumulation, and significant upregulation of the expression of vasculoprotective NADPH oxidase 4 [18]