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This lipid peroxidation product can also alter intracellular calcium levels and mitochondrial membrane potential, further promoting the intrinsic pathway of apoptosis [42]

Although Amgen did not disclose many details, management was encouraged enough to announce that the program will move to phase 3 in obesity, obesity-related indications, and diabetes, an area where theoretical concerns about blood sugar effects of the drug had previously made development less appealing

Immunology (2018) 154(2):17885

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