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We have more tools in our toolbox now, but it still needs to be done with medical guidance, Simonetti says

Direct answer: Helpful details include meal size, nausea level, vomiting episodes, bowel movements, abdominal pain, hydration, and the timing of symptoms in relation to each dose

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Only two forms of B12 are active as a coenzyme in the body: Methylcobalamin and adenosylcobalamin are the active coenzyme forms of B12

Activated p53 translocate to the nucleus, where it upregulates pro-apoptotic genes such as Bax, PUMA, and NOXA, while suppressing anti-apoptotic Bcl-2 expression (77)

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