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The ZDHHC21T209S/T209S mouse model confirms that the mutation significantly increases neuronal excitotoxicity susceptibility and triggers synaptic dysfunction by enhancing FYN palmitoylation, leading to NMDAR2B overactivation and dysfunction and neuronal loss, ultimately resulting in cognitive deficits (168)

Iran J Reprod Med

Park Relat Disord 21:10671071 Damri O, Shemesh N, Agam G (2020) Is There Justification to Treat Neurodegenerative Disorders by Repurposing Drugs

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doi: 10.1371/journal.pone.0219633 52 AzadMAKSarkerMLiTYinJ

Phosphodiesterase 3A and arterial hypertension