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Ameliorative effect of LC on TMX-induced caspase-3 and GFAP activation The levels of caspase-3 and GFAP expression were measured in the experimental groups to investigate whether LC has anti-apoptotic and anti-astrogliosis effects in the brain

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3.2 Direct hepatocyte protection: membrane stabilization and antioxidant effects 3.2.1 Membrane stabilization The amphiphilic structure of glycyrrhizin enables it to intercalate into the phospholipid bilayer of hepatocyte membranes, primarily in the outer layer