In the retatrutide Phase 2 trial (Jastreboff et al., NEJM 2023), many participants found that symptoms such as diarrhoea, nausea, and abdominal discomfort improved after the initial weeks at a given dose, consistent with experience seen with licensed GLP-1 receptor agonists
Acknowledgments We sincerely extend our gratitude to the Universit degli Studi di Parma and LIFE18 ENV/IT/000460 Life MILCH mother and infant dyads: Lowering the impact of endocrine disrupting chemicals in milk for a healthy life project for providing support for the research fellowship to A-M Shulhai
24 Therefore, considering that GLP-1R is widely distributed in the body, that COPD and diabetes interact with each other and share common pathogenic mechanisms, and that GLP-1 and its receptor agonists have been widely used in diabetic patients and have demonstrated hypoglycemic, pro-inflammatory and anti-inflammatory factors, oxidative stress, neurogenesis and vascular protection, 33 then GLP-1 and its receptor agonists also have a role to play in COPD patients
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As venoms are complex mixtures of many chemicals, exact effects are often unclear
PMID: 33934676 Nogueira LFR, Crispim CA, Cipolla-Neto J, de Castro Moreno CR, Marqueze EC (2022) The effect of exogenous melatonin on eating habits of female night workers with excessive weight