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Vilsbll T et al

In patients with renal impairment including end-stage renal disease (ESRD), no clinically relevant change in semaglutide pharmacokinetics was observed [see Clinical Pharmacology (12.3)]

Subgroup analyses (Figure 5) (exploratory) revealed similar directional trends across subgroups, including patients with organ transplantation (HR 0.27, 95% CI 0.090.82

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In addition, after high-dosage intravenous administration (50 mg/kg of body weight), Glutathione shows the following pharmacokinetic parameters in healthy volunteers