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While MPNST remains a challenging malignancy, several promising advances are underway: MEK Inhibitors in NF1-Associated MPNST Given the dysregulation of the RAS/RAF/MEK pathway in NF1-related tumors, MEK inhibitors like selumetinib have shown efficacy in benign plexiform neurofibromas
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Fearon, U., Canavan, M., Biniecka, M
After 16 weeks of liraglutide therapy, the patient achieved a 9.7 kg weight reduction, demonstrating that GLP-1 RAs can re-induce weight loss even after prior surgical failure [68]