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Treatment with the non-essential metals resulted in both enrichment and depletion of cells lacking membrane transporters, as suggested by the enrichment or depletion of the respective sgRNAs, implying that some transporters were increasing, and others decreasing, the toxicity of the three metals (Fig 2BD, Table 1)

PPMNR, RFBS and FJTH contributed to visualization

While the parabiotic model could underestimate the recruitment of circulating microglia precursors to the CNS it is still a striking finding, which could indicate that circulating monocytes are being given a greater importance in ALS disease pathogenesis than they deserve

2026 Mar 12;19(3):463

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The nausea rate of 43.2% at 12 mg is substantially higher than tirzepatide at 15 mg