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Dual GLP-1/GIP receptor agonists DA-CH3 and DA5-CH reduced GSK3 activity as well [143, 144]

These observations suggest that mild inflammatory stimuli can activate endogenous defense mechanisms that strengthen the BBB and the overall CNS resilience

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Compared with women without sickle cell disease, the review reports markedly higher risks: 6.0-times higher maternal mortality (95% CI 1.9 to 18.4) 2.4-times higher pre-eclampsia (95% CI 1.8 to 3.4) 3.9-times higher stillbirth (95% CI 2.6 to 6.0) 2.2-times higher preterm delivery (95% CI 1.5 to 3.3) 3.7-times higher small-for-gestational-age infants (95% CI 2.3 to 6.0) Much of this seems to come down to impaired placental blood flow and features of placental insufficiency