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Experts say there are a multitude of reasons, but the primary one is cost
The novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long-acting GLP-1 receptor agonists
Of those who enrolled at baseline, 7% discontinued using tirzepatide during to an adverse event and 6.5% discontinued the study
Most researchers report no issues with the injection volume at this level when using a 29 or 31 gauge needle
Sema and tirz too big to be absorbed across the oral mucosa and are rapidly and completely broken down in the stomach (unless theres a special patented absorption enhancer called SNAC technology in the case of Rybelsus, which allows a small fraction to be absorbed directly across the stomach wall)
