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Furthermore, Asn 184 cannot mediate a favorable interaction with the NADP + phosphate group (as observed in the presence of a serine or threonine)

Subsequently, c-Met is internalized and degraded promptly by the ubiquitin-proteasome degradation pathway (Naka et al., 1993

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Lower-dose signaling virtually eliminates these issues

36 Pharmacological studies in whole-animal models have demonstrated that the activation of GLP-1 receptors enhances glucose tolerance and suppresses food intake, thereby facilitating weight loss and improving glucose homeostasis

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