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327 CR may prevent AD by lowering serum tyrosine levels to reverse the exhaustion of tyrosyl-tRNA synthetase (TyrRS) and upregulating the sirtuin pathway, which attenuates the amyloidogenic processing of amyloid- protein precursor (APP), as confirmed by in vivo and in vitro models

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from moderate depression to minimal symptoms and despite a large reduction in HbA1c from 84 to 62 mmol/mol

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The main reasons are side effects, a sudden stop in weight reduction, or loss of drive