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Another drug, activated protein C, reduces BBB breakdown and leakage in stroke model rodents and has anti-inflammatory effects, neuroprotective effects, and blocks hemorrhage after brain ischemia [126, 127]

JCI Insight 8 , e167274 (2023)

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and then purified

Cancer 53 LekicT.HartmanR.RojasH.ManaenkoA.ChenW.AyerR.et al (2010)