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found that Xiangsha Liujunzi Decoction can reduce gastrointestinal inflammation by inhibiting tumor necrosis factor-alpha (TNF-) and IL-6 via downregulation of TLR4, mitogen-activated protein kinase (MAPK), nuclear factor kappa-B (NF-B), and nitric oxide (NO) levels ( In summary, the essential mechanism by which Sijunzi Decoction improves spleen deficiency is through regulating energy, restoring gastrointestinal function, and alleviating inflammation, throughout which the gut microbiota also changes