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Both retatrutide and semaglutide activate the GLP-1 receptor

Collectively, these results highlight the role of vagal afferents in mediating the metabolic and appetite-regulating effects of peripheral GLP-1, thereby linking gut-derived signals to central regulatory circuits

early weight loss during the first month therefore reflects the titration phase rather than the drug's full therapeutic effect, and precise one-month figures were not reported as primary outcomes

This dual action is what makes tirzepatide different from medications like semaglutide , which only activates the GLP-1 receptor

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