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In this review, we explore the current understanding of lipedema through clinical, tissue, and cellular lenses, and examine suspected pathological mechanisms, including hormonal influences (such as estrogen), adipocyte hypertrophy and hyperplasia, increased extracellular matrix (ECM) fibrosis, and specialized immune cell involvement, including M2 macrophage infiltration

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Last summer, Altimmune unveiled data from its Phase II MOMENTUM trial testing pemvidutide in obesity, touting 15.6% weight loss at the drugs highest dose