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If the window is kept open too long (beyond 6-8 weeks), the fibroblasts may become exhausted

M.Garca-BuenoB.et al (2018)

The first step is to measure cardiovascular risk more accurately, think in cumulative exposure rather than only 10-year horizons, use apoB where possible and especially where standard markers are most likely to underrepresent risk, intervene earlier when trajectory, family history, metabolic phenotype, or imaging suggest that the risk is being understated, and keep treatment burden proportional to the quality of evidence and the person in front of the doctor

Cameron DE, Bashor CJ, Collins JJ

Researchers proceeding with this stack should do so with conservative dosing, structured monitoring, and clear stopping criteria if adverse events emerge

Slomski, A