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The most frequently reported side effects of metformin are gastrointestinal in nature, affecting approximately 20-30% of patients

7.3 Transgenerational and epigenetic research priorities While animal studies consistently demonstrate heritable reproductive dysfunction through EED-induced epigenetic modifications, human evidence remains limited, necessitating focused research initiatives to validate these mechanisms in human populations

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While current clinical and anecdotal evidence hasnt shown an increased risk, caution makes sense, especially if you have a history of cancer or concerns about tumors

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