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A recurring pattern is transcriptional activation associated with histone lactylation, complemented by non-histone lactylation that modulates RNA metabolism and protein stability/ubiquitin signalingsupporting the view of lactylation as a modular integrator rather than a single marker

Nazem A, Tang CC, Spetsieris PG, Dresel C, Gordon ML , Diehl-Schmid J, Grimmer T, Yakushev I, Mattis P, Ma Y, Dhawan V, Eidelberg DA

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doi: 10.1016/j.tranon.2021.101174 261

Clinical significance of diffusely increased 18F-FDG uptake in the thyroid gland