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These include: Thyroid medications (levothyroxine) Certain antibiotics (gentamicin, ciprofloxacin) Antimalarial drugs (mefloquine) Chemotherapy drugs Immunologic agents such as interferon-alpha Recognizing Depression Symptoms Related To Medications Signs of Medication-Induced Depression Medication-induced depression can cause the following signs and symptoms: Persistent changes in mood Loss of interest in activities or hobbies Feelings of sadness, hopelessness, or worthlessness Changes in sleep patterns (insomnia or oversleeping) Low energy and fatigue Changes in appetite Difficulty concentrating Thoughts of death or suicide How To Tell If A Drug Is Causing Depression or Mood Changes If you start treatment with a new medication and start noticing depressive symptoms soon thereafter, you can suspect a link

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