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Notably, FoB persist in Gclc -deficient mice and are characterized by increased ROS and acquire characteristics of Gclc -sufficient MZB

Glucagon promotes hepatic glycogenolysis, stimulates gluconeogenesis, and critically, increases energy expenditure and thermogenesis

In AD, tau undergoes hyperphosphorylation and other post-translational modifications, leading to its aggregation into neurofibrillary tangles (NFTs) and disruption of neuronal function [19, 23, 24]

Therefore, its a sensitive indicator for active B12 deficiency

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