(Figure adapted from: Sen CK, Packer L: Thiol homeostasis and supplements in physical exercise
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FIGURE 5 The proteome after SARS-CoV-2 infection revealed altered expression of various cellular pathways, including the interferon-stimulated gene (ISG) signature, transcription, translation and protein degradation, the cytoskeleton, vesicular trafficking and tight junctions, apoptosis, signal transduction pathways as well as carbon, lipid and nucleotide metabolism (Figure 5A, Table 1, and Supplementary Table 3)
Overall, PAGln altered isolated cardiomyocyte contractile and calcium dynamics despite adrenergic blockade, demonstrating the direct effects of PAGln on cardiomyocytes
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