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Brit Med J 344: e1369

06/2022 to Artur Santos-Miranda)

Does Semaglutide include a COA

Theyre often used off-label for weight, but that is off-label use, not an approved weight-loss indication

This rapid degradation is the primary reason that GLP-1 receptor agonist drugs require structural modifications such as DPP-4 resistance mutations, albumin binding, or Fc fusion to achieve a pharmacologically useful duration of action